Background Osteopontin (OPN) is a pleiotropic cytokine that has been postulated to play a
role in the pathogenesis of idiopathic pulmonary arterial hypertension (IPAH). OPN plasma
levels may be related to disease severity and mortality in patients with PAH. Methods OPN
plasma levels obtained during right-sided heart catheterization were assessed by a
commercially available enzyme-linked immunosorbent assay and related to hemodynamics,
exercise capacity, N-terminal pro-brain natriuretic peptide (NT-pro-BNP) level, uric acid …