Maladaptive role of IL-6 in ischemic acute renal failure
ML Kielar, R John, M Bennett… - Journal of the …, 2005 - journals.lww.com
The role of IL-6 was investigated in murine ischemic acute renal failure. The renal pedicles
were clamped for 17 min, and the mice were studied at various times after reperfusion. We
found that serum IL-6 increased after murine ischemic renal injury. This increase was
associated with increased IL-6 mRNA in the ischemic kidney but not in the contralateral
kidney or the liver. Maximal IL-6 production occurred at 4 to 8 h and decreased to baseline
by 24 h. Reperfusion of the kidney was required for IL-6 production. In situ hybridization and …
were clamped for 17 min, and the mice were studied at various times after reperfusion. We
found that serum IL-6 increased after murine ischemic renal injury. This increase was
associated with increased IL-6 mRNA in the ischemic kidney but not in the contralateral
kidney or the liver. Maximal IL-6 production occurred at 4 to 8 h and decreased to baseline
by 24 h. Reperfusion of the kidney was required for IL-6 production. In situ hybridization and …
