Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system
RM Zinkernagel, PC Doherty - Nature, 1974 - nature.com
RM Zinkernagel, PC Doherty
Nature, 1974•nature.comRECENT experiments1–3 indicate that cooperation between thymus derived lymphocytes (T
cells) and antibody-forming cell precursors (B cells) is restricted by the H-2 gene complex.
Helper activity in vivo operates only when T cells and B cells share at least one set of H-2
antigenic specificities. Evidence is presented here that the interaction of cytotoxic T cells with
other somatic cells budding4–5 lymphocytic choriomeningitis (LCM) virus is similarly
restricted.
cells) and antibody-forming cell precursors (B cells) is restricted by the H-2 gene complex.
Helper activity in vivo operates only when T cells and B cells share at least one set of H-2
antigenic specificities. Evidence is presented here that the interaction of cytotoxic T cells with
other somatic cells budding4–5 lymphocytic choriomeningitis (LCM) virus is similarly
restricted.
Abstract
RECENT experiments1–3 indicate that cooperation between thymus derived lymphocytes (T cells) and antibody-forming cell precursors (B cells) is restricted by the H-2 gene complex. Helper activity in vivo operates only when T cells and B cells share at least one set of H-2 antigenic specificities. Evidence is presented here that the interaction of cytotoxic T cells with other somatic cells budding4–5 lymphocytic choriomeningitis (LCM) virus is similarly restricted.
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