[HTML][HTML] CXCR3 and CCR5 are both required for T cell-mediated protection against C. trachomatis infection in the murine genital mucosa
Chemokine receptors direct T lymphocytes to the site of an infection by following
coordinated chemokine gradients, which allow their recruitment to specific tissues. Although
identification of receptors needed for homing to some mucosal sites, such as skin and gut,
have been elucidated, the receptors that direct lymphocytes to the genital mucosa remain
relatively uncharacterized. In this study we identify that the chemokine receptors CXCR3
(chemokine (CXC motif) receptor 3) and CCR5 (chemokine (CC motif) receptor 5) are pivotal …
coordinated chemokine gradients, which allow their recruitment to specific tissues. Although
identification of receptors needed for homing to some mucosal sites, such as skin and gut,
have been elucidated, the receptors that direct lymphocytes to the genital mucosa remain
relatively uncharacterized. In this study we identify that the chemokine receptors CXCR3
(chemokine (CXC motif) receptor 3) and CCR5 (chemokine (CC motif) receptor 5) are pivotal …
