Intravaginal infection with herpes simplex virus type-2 (HSV-2) generates a functional effector memory T cell population that persists in the murine genital tract
VA Tang, KL Rosenthal - Journal of reproductive immunology, 2010 - Elsevier
Although the female genital tract is the main portal of entry for sexually transmitted infections
in women, we still have limited understanding of the generation, maintenance and
characteristics of memory T cells in the local tissue. Here, we utilized a mouse model of
intravaginal HSV-2 infection and tetramers against the immunodominant HSV glycoprotein B
epitope recognized by CD8+ T cells to examine the generation, maintenance and
characteristics of anti-HSV memory T cells in the genital tract following acute infection. Our …
in women, we still have limited understanding of the generation, maintenance and
characteristics of memory T cells in the local tissue. Here, we utilized a mouse model of
intravaginal HSV-2 infection and tetramers against the immunodominant HSV glycoprotein B
epitope recognized by CD8+ T cells to examine the generation, maintenance and
characteristics of anti-HSV memory T cells in the genital tract following acute infection. Our …
