[HTML][HTML] Mucosal delivery of human papillomavirus pseudovirus-encapsidated plasmids improves the potency of DNA vaccination
BS Graham, RC Kines, KS Corbett, J Nicewonger… - Mucosal …, 2010 - Elsevier
Mucosal immunization may be important for protection against pathogens whose
transmission and pathogenesis target the mucosal tissue. The capsid proteins of human
papillomavirus (HPV) confer tropism for the basal epithelium and can encapsidate DNA
during self-assembly to form pseudovirions (PsVs). Therefore, we produced mucosal
vaccine vectors by HPV PsV encapsidation of DNA plasmids expressing an experimental
antigen derived from the M and M2 proteins of respiratory syncytial virus (RSV). Intravaginal …
transmission and pathogenesis target the mucosal tissue. The capsid proteins of human
papillomavirus (HPV) confer tropism for the basal epithelium and can encapsidate DNA
during self-assembly to form pseudovirions (PsVs). Therefore, we produced mucosal
vaccine vectors by HPV PsV encapsidation of DNA plasmids expressing an experimental
antigen derived from the M and M2 proteins of respiratory syncytial virus (RSV). Intravaginal …
