[HTML][HTML] Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK
E Gensch, M Gallup, A Sucher, D Li… - Journal of Biological …, 2004 - ASBMB
In smokers' lungs, excessive mucus clogs small airways, impairing respiration and
promoting recurrent infection. A breakthrough in understanding this pathology was the
realization that smoke could directly stimulate mucin synthesis in lung epithelial cells and
that this phenomenon was dependent on the cell surface receptor for epidermal growth
factor, EGFR. Distal steps in the smoke-triggered pathway have not yet been determined.
We report here that the predominant airway mucin (MUC5AC) undergoes transcriptional up …
promoting recurrent infection. A breakthrough in understanding this pathology was the
realization that smoke could directly stimulate mucin synthesis in lung epithelial cells and
that this phenomenon was dependent on the cell surface receptor for epidermal growth
factor, EGFR. Distal steps in the smoke-triggered pathway have not yet been determined.
We report here that the predominant airway mucin (MUC5AC) undergoes transcriptional up …
