[HTML][HTML] An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress
D Yoshimura, K Sakumi, M Ohno, Y Sakai… - Journal of Biological …, 2003 - ASBMB
MTH1 hydrolyzes oxidized purine nucleoside triphosphates such as 8-oxo-2′-
deoxyguanosine 5′-triphosphate (8-oxo-dGTP) and 2-hydroxy-2′-deoxyadenosine 5′-
triphosphate (2-OH-dATP) and thus protects cells from damage caused by their
misincorporation into DNA. In the present study, we established MTH1-null mouse embryo
fibroblasts that were highly susceptible to cell dysfunction and death caused by exposure to
H 2 O 2, with morphological features of pyknosis and electron-dense deposits accumulated …
deoxyguanosine 5′-triphosphate (8-oxo-dGTP) and 2-hydroxy-2′-deoxyadenosine 5′-
triphosphate (2-OH-dATP) and thus protects cells from damage caused by their
misincorporation into DNA. In the present study, we established MTH1-null mouse embryo
fibroblasts that were highly susceptible to cell dysfunction and death caused by exposure to
H 2 O 2, with morphological features of pyknosis and electron-dense deposits accumulated …