Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney
K Tsuruya, M Furuichi, Y Tominaga, M Shinozaki… - DNA repair, 2003 - Elsevier
During ischemia-reperfusion (I/R) injury in the rat kidney, apoptosis was observed in the
distal tubules of the cortico-medullary region and outer medulla (OM) while severe necrosis
was seen in the proximal straight tubules of the OM. The majority of these changes
disappeared within 2 weeks. We examined the contents of 8-oxo-2′-deoxyguanosine (8-
oxo-dG), which is a major type of oxidative damage in DNA, in the rat kidney during I/R
injury, and also investigated the expression level of the OGG1 gene encoding the 8 …
distal tubules of the cortico-medullary region and outer medulla (OM) while severe necrosis
was seen in the proximal straight tubules of the OM. The majority of these changes
disappeared within 2 weeks. We examined the contents of 8-oxo-2′-deoxyguanosine (8-
oxo-dG), which is a major type of oxidative damage in DNA, in the rat kidney during I/R
injury, and also investigated the expression level of the OGG1 gene encoding the 8 …
