Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs
KM Veerman, MJ Williams, K Uchimura, MS Singer… - Nature …, 2007 - nature.com
KM Veerman, MJ Williams, K Uchimura, MS Singer, JS Merzaban, S Naus, DA Carlow…
Nature immunology, 2007•nature.comP-selectin glycoprotein ligand 1 (PSGL-1) is central to the trafficking of immune effector cells
to areas of inflammation through direct interactions with P-selectin, E-selectin and L-selectin.
Here we show that PSGL-1 was also required for efficient homing of resting T cells to
secondary lymphoid organs but functioned independently of selectin binding. PSGL-1
mediated an enhanced chemotactic T cell response to the secondary lymphoid organ
chemokines CCL21 and CCL19 but not to CXCL12 or to inflammatory chemokines. Our data …
to areas of inflammation through direct interactions with P-selectin, E-selectin and L-selectin.
Here we show that PSGL-1 was also required for efficient homing of resting T cells to
secondary lymphoid organs but functioned independently of selectin binding. PSGL-1
mediated an enhanced chemotactic T cell response to the secondary lymphoid organ
chemokines CCL21 and CCL19 but not to CXCL12 or to inflammatory chemokines. Our data …
Abstract
P-selectin glycoprotein ligand 1 (PSGL-1) is central to the trafficking of immune effector cells to areas of inflammation through direct interactions with P-selectin, E-selectin and L-selectin. Here we show that PSGL-1 was also required for efficient homing of resting T cells to secondary lymphoid organs but functioned independently of selectin binding. PSGL-1 mediated an enhanced chemotactic T cell response to the secondary lymphoid organ chemokines CCL21 and CCL19 but not to CXCL12 or to inflammatory chemokines. Our data show involvement of PSGL-1 in facilitating the entry of T cells into secondary lymphoid organs, thereby demonstrating the bifunctional nature of this molecule.
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