The anaphase promoting complex/cyclosome: a machine designed to destroy
JM Peters - Nature reviews Molecular cell biology, 2006 - nature.com
Nature reviews Molecular cell biology, 2006•nature.com
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has
essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular
machine that is known to catalyse ubiquitylation reactions, and it contains more than a
dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have
revealed an unexpected multitude of mechanisms that control APC/C activity, and have
provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.
essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular
machine that is known to catalyse ubiquitylation reactions, and it contains more than a
dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have
revealed an unexpected multitude of mechanisms that control APC/C activity, and have
provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.
Abstract
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.
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