Strychnine binding associated with glycine receptors of the central nervous system
AB Young, SH Snyder - Proceedings of the National …, 1973 - National Acad Sciences
AB Young, SH Snyder
Proceedings of the National Academy of Sciences, 1973•National Acad Sciences[3H] Strychnine binds to synaptic-membrane fractions of the spinal cord in a selective
fashion, indicating an interaction with postsynaptic glycine receptors. Displacement of
strychnine by glycine and other amino acids parallels their glycine-like neurophysiologic
activity. The regional localization of strychnine binding in the central nervous system
correlates closely with endogenous glycine concentrations. In subcellular fractionation
experiments, strychnine binding is most enhanced in synaptic-membrane fractions …
fashion, indicating an interaction with postsynaptic glycine receptors. Displacement of
strychnine by glycine and other amino acids parallels their glycine-like neurophysiologic
activity. The regional localization of strychnine binding in the central nervous system
correlates closely with endogenous glycine concentrations. In subcellular fractionation
experiments, strychnine binding is most enhanced in synaptic-membrane fractions …
[3H]Strychnine binds to synaptic-membrane fractions of the spinal cord in a selective fashion, indicating an interaction with postsynaptic glycine receptors. Displacement of strychnine by glycine and other amino acids parallels their glycine-like neurophysiologic activity. The regional localization of strychnine binding in the central nervous system correlates closely with endogenous glycine concentrations. In subcellular fractionation experiments, strychnine binding is most enhanced in synaptic-membrane fractions. Strychnine binding is saturable, with affinity constants for glycine and strychnine of 10 and 0.03 μM, respectively.
National Acad Sciences
