Sphingosine kinase 1 regulates mucin production via ERK phosphorylation
Y Kono, T Nishiuma, T Okada, K Kobayashi… - Pulmonary …, 2010 - Elsevier
Our previous report showed that inhibition of sphingosine kinase (SphK) ameliorates
eosinophilic inflammation and mucin production in a mouse asthmatic model. To clarify the
role of SphK in airway mucin production, we utilized the mouse asthmatic model and found
that both SphK and MUC5AC expression were increased and co-localized in airway
epithelium. Next we cultured normal human bronchial epithelial cells in an air–liquid
interface and treated with IL-13 to induce their differentiation into goblet cells. We found that …
eosinophilic inflammation and mucin production in a mouse asthmatic model. To clarify the
role of SphK in airway mucin production, we utilized the mouse asthmatic model and found
that both SphK and MUC5AC expression were increased and co-localized in airway
epithelium. Next we cultured normal human bronchial epithelial cells in an air–liquid
interface and treated with IL-13 to induce their differentiation into goblet cells. We found that …
