[HTML][HTML] Both cleavage products of the mCLCA3 protein are secreted soluble proteins
L Mundhenk, M Alfalah, RC Elble, BU Pauli… - Journal of biological …, 2006 - ASBMB
Members of the chloride channels, calcium-activated (CLCA) family of proteins and in
particular the murine mCLCA3 (alias gob-5) and its human ortholog hCLCA1 have been
identified as clinically relevant molecules in diseases with secretory dysfunctions including
asthma and cystic fibrosis. Initial studies have indicated that these proteins evoke a calcium-
activated chloride conductance when transfected into human embryonic kidney cells 293
cells. However, it is not yet clear whether the CLCA proteins form chloride channels per se …
particular the murine mCLCA3 (alias gob-5) and its human ortholog hCLCA1 have been
identified as clinically relevant molecules in diseases with secretory dysfunctions including
asthma and cystic fibrosis. Initial studies have indicated that these proteins evoke a calcium-
activated chloride conductance when transfected into human embryonic kidney cells 293
cells. However, it is not yet clear whether the CLCA proteins form chloride channels per se …
