[HTML][HTML] Interleukin-1β and tumor necrosis factor-α induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases …
Mucin hypersecretion is commonly observed in many inflammatory diseases of the
respiratory tract. MUC5AC is generally recognized to be a major airway mucin because
MUC5AC is highly expressed in the goblet cells of human airway epithelium. Moreover, it is
regulated by various inflammatory cytokines. However, the mechanisms by which the
interleukin (IL)-1β and tumor necrosis factor (TNF)-α induce MUC5AC gene expression in
normal nasal epithelial cells, and the signal molecules involved, especially in the …
respiratory tract. MUC5AC is generally recognized to be a major airway mucin because
MUC5AC is highly expressed in the goblet cells of human airway epithelium. Moreover, it is
regulated by various inflammatory cytokines. However, the mechanisms by which the
interleukin (IL)-1β and tumor necrosis factor (TNF)-α induce MUC5AC gene expression in
normal nasal epithelial cells, and the signal molecules involved, especially in the …
