3-Amino-pyrazolo [3, 4-d] pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead
M Soth, S Abbot, A Abubakari, N Arora… - Bioorganic & medicinal …, 2011 - Elsevier
M Soth, S Abbot, A Abubakari, N Arora, H Arzeno, R Billedeau, N Dewdney, K Durkin…
Bioorganic & medicinal chemistry letters, 2011•Elsevier3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: Design and development to a
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Bioorganic & Medicinal Chemistry Letters Volume 21, Issue 11, 1 June 2011, Pages
3452-3456 Bioorganic & Medicinal Chemistry Letters 3-Amino-pyrazolo[3,4-d]pyrimidines as
p38α kinase inhibitors: Design and development to a highly selective lead Author links open …
highly selective lead - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals
& Books Search RegisterSign in View PDF Download full issue Search ScienceDirect Elsevier
Bioorganic & Medicinal Chemistry Letters Volume 21, Issue 11, 1 June 2011, Pages
3452-3456 Bioorganic & Medicinal Chemistry Letters 3-Amino-pyrazolo[3,4-d]pyrimidines as
p38α kinase inhibitors: Design and development to a highly selective lead Author links open …
Abstract
Learnings from previous Roche p38-selective inhibitors were applied to a new fragment hit, which was optimized to a potent, exquisitely selective preclinical lead with a good pharmacokinetic profile.
Elsevier
