p38 mitogen-activated protein kinase pathways in asthma and COPD
KF Chung - Chest, 2011 - Elsevier
The mitogen-activated protein kinase (MAPK) family includes the p38 kinases, which consist
of highly conserved proline-directed serine-threonine protein kinases that are activated in
response to inflammatory signals. Of the four isoforms, p38α is the most abundant in
inflammatory cells and has been the most studied through mainly the availability of small
molecule inhibitors. The p38 substrates include transcription factors; other protein kinases,
which in turn phosphorylate transcription factors; cytoskeletal proteins and translational …
of highly conserved proline-directed serine-threonine protein kinases that are activated in
response to inflammatory signals. Of the four isoforms, p38α is the most abundant in
inflammatory cells and has been the most studied through mainly the availability of small
molecule inhibitors. The p38 substrates include transcription factors; other protein kinases,
which in turn phosphorylate transcription factors; cytoskeletal proteins and translational …
