The low-resolution structure of nHDL reconstituted with DMPC with and without cholesterol reveals a mechanism for particle expansion [S]
V Gogonea, GS Gerstenecker, Z Wu, X Lee… - Journal of lipid …, 2013 - ASBMB
Small-angle neutron scattering (SANS) with contrast variation was used to obtain the low-
resolution structure of nascent HDL (nHDL) reconstituted with dimyristoyl
phosphatidylcholine (DMPC) in the absence and presence of cholesterol,[apoA1: DMPC (1:
80, mol: mol) and apoA1: DMPC: cholesterol (1: 86: 9, mol: mol: mol)]. The overall shape of
both particles is discoidal with the low-resolution structure of apoA1 visualized as an open,
contorted, and out of plane conformation with three arms in nascent HDL/dimyristoyl …
resolution structure of nascent HDL (nHDL) reconstituted with dimyristoyl
phosphatidylcholine (DMPC) in the absence and presence of cholesterol,[apoA1: DMPC (1:
80, mol: mol) and apoA1: DMPC: cholesterol (1: 86: 9, mol: mol: mol)]. The overall shape of
both particles is discoidal with the low-resolution structure of apoA1 visualized as an open,
contorted, and out of plane conformation with three arms in nascent HDL/dimyristoyl …
