Tolerance induction with T cell–dependent protein antigens induces regulatory sialylated IgGs
CM Oefner, A Winkler, C Hess, AK Lorenz… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Under inflammatory conditions, T cell–dependent (TD) protein antigens
induce proinflammatory T-and B-cell responses. In contrast, tolerance induction by TD
antigens without costimulation triggers the development of regulatory T cells. Under both
conditions, IgG antibodies are generated, but whether they have different immunoregulatory
functions remains elusive. OBJECTIVE: It was shown recently that proinflammatory or anti-
inflammatory effector functions of IgG molecules are determined by different Fc N-linked …
induce proinflammatory T-and B-cell responses. In contrast, tolerance induction by TD
antigens without costimulation triggers the development of regulatory T cells. Under both
conditions, IgG antibodies are generated, but whether they have different immunoregulatory
functions remains elusive. OBJECTIVE: It was shown recently that proinflammatory or anti-
inflammatory effector functions of IgG molecules are determined by different Fc N-linked …