Antibodies of all classes and subclasses except IgD have been shown to have the capacity
to feedback regulate the production of themselves [1]. This phenomenon has been known
for over a century and was originally described by the first Nobel laureate in physiology, Emil
von Behring [2]. When an animal is immunized with antibodies together with an antigen they
recognize, the antibody response to this very antigen is often dramatically modulated.
Sometimes feedback regulation results in complete suppression and sometimes in several …