Suppression of IL-4-and CD40-induced B-lymphocyte activation by intravenous immunoglobulin is not mediated through the inhibitory IgG receptor FcγRIIb
Q Zhuang, S Bisotto, ED Fixman, B Mazer - Journal of allergy and clinical …, 2002 - Elsevier
Background: Intravenous immunoglobulin (IVIG) has been used extensively in the treatment
of autoimmune and allergic diseases, but the precise mechanism behind its efficacy remains
unclear. Ligation of the low-affinity IgG Fc receptor FcγRIIb can inhibit B-lymphocyte
activation. Our laboratory has shown that IVIG suppresses proliferation and IgE production
by human B cells stimulated with IL-4 and anti-CD40 antibodies. Objective: We sought to
determine whether the regulatory action of IVIG is mediated through binding FcγRIIb …
of autoimmune and allergic diseases, but the precise mechanism behind its efficacy remains
unclear. Ligation of the low-affinity IgG Fc receptor FcγRIIb can inhibit B-lymphocyte
activation. Our laboratory has shown that IVIG suppresses proliferation and IgE production
by human B cells stimulated with IL-4 and anti-CD40 antibodies. Objective: We sought to
determine whether the regulatory action of IVIG is mediated through binding FcγRIIb …