[HTML][HTML] Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma
E Castoldi, P Simioni, D Tormene, J Rosing… - Journal of thrombosis …, 2010 - Elsevier
Background: Protein S and tissue factor pathway inhibitor (TFPI) act together in down‐
regulating coagulation. Objective: To investigate the TFPI/protein S system in hereditary and
acquired protein S deficiency. Methods: Plasma antigen levels of protein S and full‐length
TFPI were determined in heterozygous type I protein S‐deficient individuals (n= 35), patients
on oral anticoagulant treatment (OAT)(n= 29), oral contraceptive (OC) users (n= 10) and
matched controls. Thrombin generation was determined using calibrated automated …
regulating coagulation. Objective: To investigate the TFPI/protein S system in hereditary and
acquired protein S deficiency. Methods: Plasma antigen levels of protein S and full‐length
TFPI were determined in heterozygous type I protein S‐deficient individuals (n= 35), patients
on oral anticoagulant treatment (OAT)(n= 29), oral contraceptive (OC) users (n= 10) and
matched controls. Thrombin generation was determined using calibrated automated …
