The biology of human lymphoid malignancies revealed by gene expression profiling
LM Staudt, S Dave - Advances in immunology, 2005 - Elsevier
Gene expression profiling provides a quantitative molecular framework for the study of
human lymphomas. This genomic technology has revealed that existing diagnostic
categories are comprised of multiple molecularly and clinically distinct diseases. Diffuse
large B‐cell lymphoma (DLBCL), for example, consists of three gene expression subgroups,
termed germinal center B‐cell–like (GCB) DLBCL, activated B‐cell–like (ABC) DLBCL, and
primary mediastinal B‐cell lymphoma (PMBL). These DLBCL subgroups arise from different …
human lymphomas. This genomic technology has revealed that existing diagnostic
categories are comprised of multiple molecularly and clinically distinct diseases. Diffuse
large B‐cell lymphoma (DLBCL), for example, consists of three gene expression subgroups,
termed germinal center B‐cell–like (GCB) DLBCL, activated B‐cell–like (ABC) DLBCL, and
primary mediastinal B‐cell lymphoma (PMBL). These DLBCL subgroups arise from different …
