Airway vascular changes after lung transplant: potential contribution to the pathophysiology of bronchiolitis obliterans syndrome
SY Langenbach, L Zheng, T McWilliams… - The Journal of heart and …, 2005 - Elsevier
BACKGROUND: Bronchiolitis obliterans syndrome (BOS) remains the primary factor limiting
successful lung transplantation. In asthma and lung transplantation BOS-increased sub-
mucosal vascularity has been shown to contribute to airflow limitation. Vascularity has 2
components: sprouting angiogenesis (more vessels) and microvascular enlargement (larger
vessels). We hypothesized that the lack of a reanastomosed bronchial arterial blood supply
at the time of transplant might stimulate angiogenesis and be a risk factor for subsequent …
successful lung transplantation. In asthma and lung transplantation BOS-increased sub-
mucosal vascularity has been shown to contribute to airflow limitation. Vascularity has 2
components: sprouting angiogenesis (more vessels) and microvascular enlargement (larger
vessels). We hypothesized that the lack of a reanastomosed bronchial arterial blood supply
at the time of transplant might stimulate angiogenesis and be a risk factor for subsequent …