Hypoxia is associated with extracellular matrix remodeling in several inflammatory lung
diseases, such as fibrosis, chronic obstructive pulmonary disease, and asthma. In a human
cell culture model, we assessed whether extracellular matrix modification by hypoxia and
platelet-derived growth factor (PDGF) involves the action of matrix metalloproteinases
(MMPs) and thereby affects cell proliferation. Expression of MMP and its activity were
assessed by zymography and enzyme-linked immunosorbent assay in human lung …