How MHC class II molecules work: peptide-dependent completion of protein folding
S Sadegh-Nasseri, RN Germain - Immunology today, 1992 - Elsevier
It is now clear that peptides play a key role in stabilizing the structure of MHC class II
molecules. Here, Scheherazade Sadegh-Nasseri and Ron Germain propose that newly
synthesized MHC class II, and indeed class I, molecules behave like partially folded
proteins, with peptides acting as a surrogate portion of the MHC polypeptide structure that is
necessary for completion of conformational maturation.
molecules. Here, Scheherazade Sadegh-Nasseri and Ron Germain propose that newly
synthesized MHC class II, and indeed class I, molecules behave like partially folded
proteins, with peptides acting as a surrogate portion of the MHC polypeptide structure that is
necessary for completion of conformational maturation.