Cardiomyocyte survivin protein expression is associated with cell size and DNA content in the failing human heart and is reversibly regulated after ventricular …
J Wohlschlaeger, B Meier, KJ Schmitz, A Takeda… - The Journal of heart and …, 2010 - Elsevier
BACKGROUND:: Mechanical support in congestive heart failure (CHF) by a left ventricular
assist device (LVAD) is associated with decreased cardiac hypertrophy and altered
cardiomyocyte molecular pathways. Survivin initiates cell cycle progression by increased
cyclinD1/cdk4 complexes by abrogation of the inhibitory effect of p16INK4a on cdk4.
Accordingly, the role of survivin in CHF and after unloading was explored. METHODS:: In 20
myocardial samples from patients with terminal CHF (before and after LVAD), the protein …
assist device (LVAD) is associated with decreased cardiac hypertrophy and altered
cardiomyocyte molecular pathways. Survivin initiates cell cycle progression by increased
cyclinD1/cdk4 complexes by abrogation of the inhibitory effect of p16INK4a on cdk4.
Accordingly, the role of survivin in CHF and after unloading was explored. METHODS:: In 20
myocardial samples from patients with terminal CHF (before and after LVAD), the protein …
