[HTML][HTML] Ca2+-independent phospholipase A2 is required for agonist-induced Ca2+ sensitization of contraction in vascular smooth muscle
Z Guo, W Su, Z Ma, GM Smith, MC Gong - Journal of Biological Chemistry, 2003 - ASBMB
Excitatory agonists can induce significant smooth muscle contraction under constant free Ca
2+ through a mechanism called Ca 2+ sensitization. Considerable evidence suggests that
free arachidonic acid plays an important role in mediating agonist-induced Ca 2+-
sensitization; however, the molecular mechanisms responsible for maintaining and
regulating free arachidonic acid level are not completely understood. In the current study, we
demonstrated that Ca 2+-independent phospholipase A 2 (iPLA 2) is expressed in vascular …
2+ through a mechanism called Ca 2+ sensitization. Considerable evidence suggests that
free arachidonic acid plays an important role in mediating agonist-induced Ca 2+-
sensitization; however, the molecular mechanisms responsible for maintaining and
regulating free arachidonic acid level are not completely understood. In the current study, we
demonstrated that Ca 2+-independent phospholipase A 2 (iPLA 2) is expressed in vascular …
