[HTML][HTML] Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 transcriptional …
Mice deficient in regulator of G-protein signaling-2 (RGS2) have severe hypertension, and
RGS2 genetic variations occur in hypertensive humans. A potentially important negative
feedback loop in blood pressure homeostasis is that angiotensin II (Ang II) increases
vascular smooth muscle cell (VSMC) RGS2 expression. We reported that Group VIA
phospholipase A 2 (iPLA 2 β) is required for this response (Xie, Z., Gong, MC, Su, W., Turk,
J., and Guo, Z.(2007) J. Biol. Chem. 282, 25278–25289), but the specific molecular causes …
RGS2 genetic variations occur in hypertensive humans. A potentially important negative
feedback loop in blood pressure homeostasis is that angiotensin II (Ang II) increases
vascular smooth muscle cell (VSMC) RGS2 expression. We reported that Group VIA
phospholipase A 2 (iPLA 2 β) is required for this response (Xie, Z., Gong, MC, Su, W., Turk,
J., and Guo, Z.(2007) J. Biol. Chem. 282, 25278–25289), but the specific molecular causes …
