Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice
T Hammerschmidt, MP Kummer, D Terwel… - Biological …, 2013 - Elsevier
BACKGROUND: Degeneration of the locus coeruleus (LC), the major noradrenergic nucleus
in the brain, occurs early and is ubiquitous in Alzheimer's disease (AD). Experimental
lesions to the LC exacerbate AD-like neuropathology and cognitive deficits in several
transgenic mouse models of AD. Because the LC contains multiple neuromodulators known
to affect amyloid β toxicity and cognitive function, the specific role of noradrenaline (NA) in
AD is not well understood. METHODS: To determine the consequences of selective NA …
in the brain, occurs early and is ubiquitous in Alzheimer's disease (AD). Experimental
lesions to the LC exacerbate AD-like neuropathology and cognitive deficits in several
transgenic mouse models of AD. Because the LC contains multiple neuromodulators known
to affect amyloid β toxicity and cognitive function, the specific role of noradrenaline (NA) in
AD is not well understood. METHODS: To determine the consequences of selective NA …