Tumor necrosis factor α and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease
EM Ramos, MT Lin, EB Larson, I Maezawa… - Archives of …, 2006 - jamanetwork.com
Background Functional polymorphisms in tumor necrosis factor α (TNF-α) and interleukin 10
(IL-10) can affect immune response, inflammation, tissue injury, and possibly the
susceptibility to Alzheimer disease (AD). Objective To evaluate the association between
promoter region polymorphisms in theTNF-α andIL-10genes and risk of late-onset AD in
older white subjects. Design Community-based case-control study. Setting Group Health
Cooperative of Puget Sound. Participants White subjects (n= 265) meeting criteria for …
(IL-10) can affect immune response, inflammation, tissue injury, and possibly the
susceptibility to Alzheimer disease (AD). Objective To evaluate the association between
promoter region polymorphisms in theTNF-α andIL-10genes and risk of late-onset AD in
older white subjects. Design Community-based case-control study. Setting Group Health
Cooperative of Puget Sound. Participants White subjects (n= 265) meeting criteria for …