Poor prognosis in breast carcinomas correlates with increased expression of targetable CD146 and c-Met and with proteomic basal-like phenotype
S Garcia, JP Dalès, E Charafe-Jauffret… - Human pathology, 2007 - Elsevier
Genomic studies have led to new taxonomic classifications of breast carcinomas. Proteomic
investigations using tissue microarrays have yielded complementary results and are useful
in identifying potential molecular targets for specific therapies. Searching for new drug
targets is particularly important for tumors of poor prognosis, such as breast tumors that lack
estrogen receptors and HER2 amplification; in these tumors, certain molecules probably
play a significant role in tumor spreading through the stromal microvasculature. We …
investigations using tissue microarrays have yielded complementary results and are useful
in identifying potential molecular targets for specific therapies. Searching for new drug
targets is particularly important for tumors of poor prognosis, such as breast tumors that lack
estrogen receptors and HER2 amplification; in these tumors, certain molecules probably
play a significant role in tumor spreading through the stromal microvasculature. We …