Human mast cells arise from a common circulating progenitor
K Maaninka, J Lappalainen, PT Kovanen - Journal of allergy and clinical …, 2013 - Elsevier
Background Human tissue mast cells (MCs) have the potential to express several neutral
granule proteases, which are the most precise markers of the phenotypic heterogeneity of
MCs. However, the full extent of such heterogeneity is limited by the fact that MCs containing
either tryptase only or tryptase and chymase have long been considered to be the sole MC
phenotypes. Moreover, the potential developmental relationship between human MCs of
different protease phenotypes has remained a matter of dispute. Objective We attempted to …
granule proteases, which are the most precise markers of the phenotypic heterogeneity of
MCs. However, the full extent of such heterogeneity is limited by the fact that MCs containing
either tryptase only or tryptase and chymase have long been considered to be the sole MC
phenotypes. Moreover, the potential developmental relationship between human MCs of
different protease phenotypes has remained a matter of dispute. Objective We attempted to …
