[HTML][HTML] 37-kDa laminin receptor precursor modulates cytotoxic necrotizing factor 1–mediated RhoA activation and bacterial uptake
JW Chung, SJ Hong, KJ Kim, D Goti, MF Stins… - Journal of Biological …, 2003 - ASBMB
Cytotoxic necrotizing factor 1 (CNF1) is a bacterial toxin known to activate Rho GTPases and
induce host cell cytoskeleton rearrangements. The constitutive activation of Rho GTPases by
CNF1 is shown to enhance bacterial uptake in epithelial cells and human brain
microvascular endothelial cells. However, it is unknown how exogenous CNF1 exhibits such
phenotypes in eukaryotic cells. Here, we identified 37-kDa laminin receptor precursor (LRP)
as the receptor for CNF1 from screening the cDNA library of human brain microvascular …
induce host cell cytoskeleton rearrangements. The constitutive activation of Rho GTPases by
CNF1 is shown to enhance bacterial uptake in epithelial cells and human brain
microvascular endothelial cells. However, it is unknown how exogenous CNF1 exhibits such
phenotypes in eukaryotic cells. Here, we identified 37-kDa laminin receptor precursor (LRP)
as the receptor for CNF1 from screening the cDNA library of human brain microvascular …
