Cerebral heme oxygenase 1 and 2 spatial distribution is modulated following injury from hypoxia–ischemia and middle cerebral artery occlusion in rats
BA Sutherland, RMA Rahman, AN Clarkson… - Neuroscience …, 2009 - Elsevier
The regional and cellular distribution of heme oxygenase (HO)-1 and-2 following cerebral
ischemia has not been ascertained. Employing the transient middle cerebral artery
occlusion (MCAO) and hypoxia–ischemia (HI) models of unilateral brain injury, the aim was
to elucidate immunolocalization of HO-1 and HO-2. Animals were sacrificed 3 days post-
ischemia and immunohistochemistry and Western blotting were utilized to determine HO-1
and HO-2 expression. In the ipsilateral hemisphere following HI, HO-1 immunoreactivity was …
ischemia has not been ascertained. Employing the transient middle cerebral artery
occlusion (MCAO) and hypoxia–ischemia (HI) models of unilateral brain injury, the aim was
to elucidate immunolocalization of HO-1 and HO-2. Animals were sacrificed 3 days post-
ischemia and immunohistochemistry and Western blotting were utilized to determine HO-1
and HO-2 expression. In the ipsilateral hemisphere following HI, HO-1 immunoreactivity was …
