Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP

MG Weisskopf, PE Castillo, RA Zalutsky, RA Nicoll - Science, 1994 - science.org
MG Weisskopf, PE Castillo, RA Zalutsky, RA Nicoll
Science, 1994science.org
Repetitive activation of hippocampal mossy fibers evokes a long-term potentiation (LTP) of
synaptic responses in pyramidal cells in the CA3 region that is independent of N-methyl-D-
aspartate receptor activation. Previous results suggest that the site for both the induction and
expression of this form of LTP is presynaptic. Experimental elevation of cyclic adenosine
3′, 5′-monophosphate (cAMP) both mimics and interferes with tetanus-induced mossy
fiber LTP, and blockers of the cAMP cascade block mossy fiber LTP. It is proposed that …
Repetitive activation of hippocampal mossy fibers evokes a long-term potentiation (LTP) of synaptic responses in pyramidal cells in the CA3 region that is independent of N-methyl-D-aspartate receptor activation. Previous results suggest that the site for both the induction and expression of this form of LTP is presynaptic. Experimental elevation of cyclic adenosine 3′,5′-monophosphate (cAMP) both mimics and interferes with tetanus-induced mossy fiber LTP, and blockers of the cAMP cascade block mossy fiber LTP. It is proposed that calcium entry into the presynaptic terminal may activate Ca2+-calmodulin-sensitive adenylyl cyclase I which, through protein kinase A, causes a persistent enhancement of evoked glutamate release.
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