Anemia induces accumulation of erythropoietin mRNA in the kidney and liver
MC Bondurant, MJ Koury - Molecular and cellular biology, 1986 - Am Soc Microbiol
MC Bondurant, MJ Koury
Molecular and cellular biology, 1986•Am Soc MicrobiolRegulation of the production of erythropoietin occurs in the kidney and liver largely through
control of accumulation of erythropoietin mRNA. Erythropoietin mRNA was first detected in
kidneys at 1.5 h postanemia and reached a plateau value at least 200-fold above the control
value by 4 to 8 h. A 20-base sequence immediately upstream from the reported
erythropoietin mRNA initiation site is complementary to a hypervariable sequence in 18S
rRNA.
control of accumulation of erythropoietin mRNA. Erythropoietin mRNA was first detected in
kidneys at 1.5 h postanemia and reached a plateau value at least 200-fold above the control
value by 4 to 8 h. A 20-base sequence immediately upstream from the reported
erythropoietin mRNA initiation site is complementary to a hypervariable sequence in 18S
rRNA.
Abstract
Regulation of the production of erythropoietin occurs in the kidney and liver largely through control of accumulation of erythropoietin mRNA. Erythropoietin mRNA was first detected in kidneys at 1.5 h postanemia and reached a plateau value at least 200-fold above the control value by 4 to 8 h. A 20-base sequence immediately upstream from the reported erythropoietin mRNA initiation site is complementary to a hypervariable sequence in 18S rRNA.
American Society for Microbiology