Cutaneous pathology in primary erythermalgia

JPH Drenth, V Vuzevski, T Van Joost… - The American journal …, 1996 - journals.lww.com
Primary or idiopathic erythermalgia is characterized by recurrent, red, warm, and painful
lower extremities. It arises at young age and persists throughout life because no treatment is
available. We report the cutaneous pathology of affected skin lesions of three patients with
primary erythermalgia. Biopsy specimens showed a mild perivascular mononuclear infiltrate,
thickened blood vessel basement membranes, abundant perivascular edema, and
moderate endothelial swelling. The thickened basal membrane of the blood vessels showed …