Altered gene expression during differentiation: population changes in hybridizable RNA after stimulation of the chick oviduct with oestrogen
BW O'MALLEY, WL McGuire, PA Middleton - Nature, 1968 - nature.com
BW O'MALLEY, WL McGuire, PA Middleton
Nature, 1968•nature.comTHE molecular control mechanisms regulating embryogenesis are not fully defined. The
appearance of morphological differentiation must reflect prior biochemical differentiation and
changes in patterns of protein synthesis. In spite of the well documented evidence that m
RNA is present before the eggs are fertilized1, it seems plausible that new m RNA also
appears during embryonic differentiation. Adult tissue-specific proteins may then be
synthesized in response to the appearance of these new chemical signals. Using …
appearance of morphological differentiation must reflect prior biochemical differentiation and
changes in patterns of protein synthesis. In spite of the well documented evidence that m
RNA is present before the eggs are fertilized1, it seems plausible that new m RNA also
appears during embryonic differentiation. Adult tissue-specific proteins may then be
synthesized in response to the appearance of these new chemical signals. Using …
Abstract
THE molecular control mechanisms regulating embryogenesis are not fully defined. The appearance of morphological differentiation must reflect prior biochemical differentiation and changes in patterns of protein synthesis. In spite of the well documented evidence that mRNA is present before the eggs are fertilized1, it seems plausible that new mRNA also appears during embryonic differentiation. Adult tissue-specific proteins may then be synthesized in response to the appearance of these new chemical signals. Using hybridization techniques, the emergence of new mRNA species has been reported during amphibian2 and sea urchin3 development.
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