[HTML][HTML] Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome
JM Busillo, KM Azzam, JA Cidlowski - Journal of Biological Chemistry, 2011 - ASBMB
Glucocorticoids have long been recognized as powerful anti-inflammatory compounds that
are one of the most widely prescribed classes of drugs in the world. However, their role in
the regulation of innate immunity is not well understood. We sought to examine the effects of
glucocorticoids on the NOD-like receptors (NLRs), a central component of the
inflammasome and innate immunity. Surprisingly, we show that glucocorticoids induce both
NLRP3 messenger RNA and protein, which is a critical component of the inflammasome …
are one of the most widely prescribed classes of drugs in the world. However, their role in
the regulation of innate immunity is not well understood. We sought to examine the effects of
glucocorticoids on the NOD-like receptors (NLRs), a central component of the
inflammasome and innate immunity. Surprisingly, we show that glucocorticoids induce both
NLRP3 messenger RNA and protein, which is a critical component of the inflammasome …