[HTML][HTML] Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA
DA Braasch, DR Corey - Chemistry & biology, 2001 - cell.com
DA Braasch, DR Corey
Chemistry & biology, 2001•cell.comLocked nucleic acid is an RNA derivative in which the ribose ring is constrained by a
methylene linkage between the 2′-oxygen and the 4′-carbon. This conformation
restriction increases binding affinity for complementarity sequences and provides an exciting
new chemical approach for the control of gene expression and optimization of microarrays.
methylene linkage between the 2′-oxygen and the 4′-carbon. This conformation
restriction increases binding affinity for complementarity sequences and provides an exciting
new chemical approach for the control of gene expression and optimization of microarrays.
Abstract
Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2′-oxygen and the 4′-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays.
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