Chemical modifications rescue off-target effects of RNAi

O Snøve Jr, JJ Rossi - ACS chemical biology, 2006 - ACS Publications
O Snøve Jr, JJ Rossi
ACS chemical biology, 2006ACS Publications
Chemical Modifications Rescue Off-Target Effects of RNAi | ACS Chemical Biology ACS ACS
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My Activity Recently Viewed Square-Planar Bis(triisopropylstibine)(olefin)iridium(I) Complexes
and Their Rearrangement to (η3-Allyl)hydridoiridium(III) Isomers Reactions of Epoxy Ketones …
RNAi’s specificity has been questioned for some time. Three recent papers show that off-target effects should be considered normal, but one paper also provides insight on how chemical modifications of siRNAs may overcome the problem.
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