Decrease in airway mucous gene expression caused by treatment with anti-tumor necrosis factor α in a murine model of allergic asthma
PJ Busse, TF Zhang, B Schofield, S Kilaru… - Annals of Allergy …, 2009 - Elsevier
BACKGROUND: Mucous hypersecretion increases asthma morbidity and mortality. Tumor
necrosis factor α (TNF-α) levels are elevated in bronchoalveolar fluid, sputum, and monocyte
membranes in some patients with asthma. Anti-TNF-α decreased asthma exacerbations and
improved forced expiratory volume in 1 second in these patients. Whether anti-TNF-α
reduces mucous cell metaplasia or hyperplasia has not been evaluated. OBJECTIVE: To
investigate the role of anti-TNF-α in mucous hypersecretion. METHODS: BALB/c mice …
necrosis factor α (TNF-α) levels are elevated in bronchoalveolar fluid, sputum, and monocyte
membranes in some patients with asthma. Anti-TNF-α decreased asthma exacerbations and
improved forced expiratory volume in 1 second in these patients. Whether anti-TNF-α
reduces mucous cell metaplasia or hyperplasia has not been evaluated. OBJECTIVE: To
investigate the role of anti-TNF-α in mucous hypersecretion. METHODS: BALB/c mice …