Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo …
N Samadi, R Bekele, D Capatos, G Venkatraman… - Biochimie, 2011 - Elsevier
Evidence from clinical, animal and cell culture studies demonstrates that increased autotaxin
(ATX) expression is responsible for enhancing tumor progression, cell migration,
metastases, angiogenesis and chemo-resistance. These effects depend mainly on the rapid
formation of lysophosphatidate (LPA) by ATX. Circulating LPA has a half-life of about 3 min
in mice and it is degraded by the ecto-activities of lipid phosphate phosphatases (LPPs).
These enzymes also hydrolyze extracellular sphingosine 1-phosphate (S1P), a potent signal …
(ATX) expression is responsible for enhancing tumor progression, cell migration,
metastases, angiogenesis and chemo-resistance. These effects depend mainly on the rapid
formation of lysophosphatidate (LPA) by ATX. Circulating LPA has a half-life of about 3 min
in mice and it is degraded by the ecto-activities of lipid phosphate phosphatases (LPPs).
These enzymes also hydrolyze extracellular sphingosine 1-phosphate (S1P), a potent signal …