Regulation of alternative splicing by histone modifications
Science, 2010•science.org
Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet
its regulation is poorly understood. We demonstrated a direct role for histone modifications
in alternative splicing. We found distinctive histone modification signatures that correlate
with the splicing outcome in a set of human genes, and modulation of histone modifications
causes splice site switching. Histone marks affect splicing outcome by influencing the
recruitment of splicing regulators via a chromatin-binding protein. These results outline an …
its regulation is poorly understood. We demonstrated a direct role for histone modifications
in alternative splicing. We found distinctive histone modification signatures that correlate
with the splicing outcome in a set of human genes, and modulation of histone modifications
causes splice site switching. Histone marks affect splicing outcome by influencing the
recruitment of splicing regulators via a chromatin-binding protein. These results outline an …
Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. We demonstrated a direct role for histone modifications in alternative splicing. We found distinctive histone modification signatures that correlate with the splicing outcome in a set of human genes, and modulation of histone modifications causes splice site switching. Histone marks affect splicing outcome by influencing the recruitment of splicing regulators via a chromatin-binding protein. These results outline an adaptor system for the reading of histone marks by the pre-mRNA splicing machinery.
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