Nafamostat mesilate is an extremely potent inhibitor of human tryptase
S Mori, Y Itoh, R Shinohata, T Sendo, R Oishi… - Journal of …, 2003 - Elsevier
S Mori, Y Itoh, R Shinohata, T Sendo, R Oishi, M Nishibori
Journal of pharmacological sciences, 2003•ElsevierPreviously, nafamostat mesilate was found to be a potent inhibitor of human tryptase. In
present study, we performed a kinetic study to determine its K i value for tryptase and
compared it with that of gabexate mesilate. Nafamostat mesilate inhibited human tryptase in
a competitive manner. The apparent K i value was estimated to be 95.3 pM, which was
1,000 times lower than that of gabexate mesilate (95.1 nM). These results strongly indicated
that nafamostat mesilate is an extremely potent inhibitor of tryptase and suggested that some …
present study, we performed a kinetic study to determine its K i value for tryptase and
compared it with that of gabexate mesilate. Nafamostat mesilate inhibited human tryptase in
a competitive manner. The apparent K i value was estimated to be 95.3 pM, which was
1,000 times lower than that of gabexate mesilate (95.1 nM). These results strongly indicated
that nafamostat mesilate is an extremely potent inhibitor of tryptase and suggested that some …
Abstract
Previously, nafamostat mesilate was found to be a potent inhibitor of human tryptase. In present study, we performed a kinetic study to determine its Ki value for tryptase and compared it with that of gabexate mesilate. Nafamostat mesilate inhibited human tryptase in a competitive manner. The apparent Ki value was estimated to be 95.3 pM, which was 1,000 times lower than that of gabexate mesilate (95.1 nM). These results strongly indicated that nafamostat mesilate is an extremely potent inhibitor of tryptase and suggested that some of its beneficial effects in the treatment of clinical status may be due to tryptase inhibition.
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