In the recent years, RNA interference (RNAi) has emerged as a major regulatory mechanism
in eukaryotic gene expression. The realization that changes in the levels of microRNAs are
directly associated with cancer led to the recognition of a new class of tumor suppressors
and oncogenes. Moreover, RNAi has been turned into a potent tool for artificially modulating
gene expression through the introduction of short interfering RNAs. A plethora of individual
inhibitory RNAs as well as several large collections of these reagents have been generated …