Structural biology of RNA silencing and its functional implications
Cold Spring Harbor symposia on quantitative biology, 2006•symposium.cshlp.org
We outline structure–function contributions from our laboratories on protein–RNA
recognition events that monitor siRNAlength, 5′-phosphate and 2-nucleotide 3′
overhangs, as well as the architecture of Argonaute, its externally bound siRNA complex,
and Argonaute-based models involving guide-strand-mediated mRNA binding, cleavage,
and release.
recognition events that monitor siRNAlength, 5′-phosphate and 2-nucleotide 3′
overhangs, as well as the architecture of Argonaute, its externally bound siRNA complex,
and Argonaute-based models involving guide-strand-mediated mRNA binding, cleavage,
and release.
Abstract
We outline structure–function contributions from our laboratories on protein–RNA recognition events that monitor siRNAlength, 5′-phosphate and 2-nucleotide 3′ overhangs, as well as the architecture of Argonaute, its externally bound siRNA complex, and Argonaute-based models involving guide-strand-mediated mRNA binding, cleavage, and release.
symposium.cshlp.org