Gene targeting via triple-helix formation
BP Casey, PM Glazer - 2001 - Elsevier
A report on a recent workshop entitled “Gene-Targeted Drugs: Function and Delivery”
conveys a justified optimism for the eventual feasibility and therapeutic benefit of gene-
targeting strategies (1). Although multiple approaches are being explored, this chapter
focuses primarily on the uses of triplex-forming oligonucleotides (TFOs). TFOs are molecules
that bind in the major groove of duplex DNA and by so doing can produce triplex structures.
They bind to the purine-rich strand of the duplex through Hoogsteen or reverse Hoogsteen …
conveys a justified optimism for the eventual feasibility and therapeutic benefit of gene-
targeting strategies (1). Although multiple approaches are being explored, this chapter
focuses primarily on the uses of triplex-forming oligonucleotides (TFOs). TFOs are molecules
that bind in the major groove of duplex DNA and by so doing can produce triplex structures.
They bind to the purine-rich strand of the duplex through Hoogsteen or reverse Hoogsteen …