Sequence-specific DNA recognition by polyamides
PB Dervan, RW Bürli - Current opinion in chemical biology, 1999 - Elsevier
PB Dervan, RW Bürli
Current opinion in chemical biology, 1999•ElsevierSequence-specific DNA-binding small molecules that can permeate cells could potentially
regulate transcription of specific genes. Simple pairing rules for the minor groove of the
double helix have been developed that allow the design of ligands for predetermined DNA
sequences. Some of these polyamides have been shown to inhibit specific gene expression
in mammalian cell culture.
regulate transcription of specific genes. Simple pairing rules for the minor groove of the
double helix have been developed that allow the design of ligands for predetermined DNA
sequences. Some of these polyamides have been shown to inhibit specific gene expression
in mammalian cell culture.
Sequence-specific DNA-binding small molecules that can permeate cells could potentially regulate transcription of specific genes. Simple pairing rules for the minor groove of the double helix have been developed that allow the design of ligands for predetermined DNA sequences. Some of these polyamides have been shown to inhibit specific gene expression in mammalian cell culture.
Elsevier